#SCIENCE: It’s in your blood!
The entire alphabet was observed in the blood smear of an 80 year old man as a result of the atypical nuclear segmentation of neutrophils. The man was hospitalized with a progressive cough, fever, dyspnea and lobar pneumonia.
Note the presence of Döhle bodies (in the letter S). Döhle bodies are intra-cytoplasmic structures composed of agglutinated ribosomes that increase in number with inflammation and increased granulocytopoiesis.When there are many neutrophils in the bloodstream containing Döhle bodies, these are referred to as toxic neutrophils consistent with a diagnosis of reactive neutrophilia secondary to acute pneumonia.
The image is based on the neutrophils observed by Adam Morgan and David Yang from the University of Wisconsin and published in the May 2013 edition of Blood.
Morgan, A.S. and Yang D.T., 2013, Neutrophil alphabet, Blood, 121 (18): 3546.